Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MDM4 | O15151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15566600 | 0.71 | HTR2C (0.43) | HDAC4HDAC8KDM4ESMN1; SMN2MDM4 | |
| SCHEMBL19933173 | 0.70 | HDAC4 (0.38) | HDAC4HDAC8KDM4ESMN1; SMN2MDM4 | |
| SCHEMBL25094188 | 0.70 | CHRNB2 (0.49) | HDAC4HDAC8KDM4ESMN1; SMN2MDM4 | |
| SCHEMBL374780 | 0.70 | HDAC4 (0.56) | HDAC4HDAC8KDM4ESMN1; SMN2MDM4 | |
| SCHEMBL15281737 | 0.68 | TSHR (0.48) | HDAC4HDAC8KDM4ESMN1; SMN2MDM4 | |
| SCHEMBL7634263 | 0.68 | HDAC4 (0.47) | HDAC4HDAC8KDM4ESMN1; SMN2MDM4 | |
| SCHEMBL1364527 | 0.68 | HTR2C (0.38) | HDAC4HDAC8KDM4ESMN1; SMN2MDM4 | |
| SCHEMBL30272547 | 0.68 | CHRNB2 (0.43) | HDAC4HDAC8KDM4ESMN1; SMN2MDM4 | |
| SCHEMBL24291779 | 0.68 | HDAC4 (0.36) | HDAC4HDAC8KDM4ESMN1; SMN2MDM4 | |
| SCHEMBL12278164 | 0.68 | HTR2C (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10206931-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10206931-B2 | Therapeutic compounds and uses thereof | EP300, CREBBP, HDAC1 | HDAC4 22/4885HDAC8 34/4885KDM4E 387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.