Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAT | P00750 | 5/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16699674 | 0.88 | PLAT (0.34) | PLATPDE4DCYP1A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL16700012 | 0.72 | ALDH1A1 (0.31) | SMN1; SMN2ALDH1A1HPGDTSHRNPSR1 | |
| SCHEMBL21130895 | 0.72 | PDE4D (0.41) | PLATPDE4DCYP1A2PDE4BMAPK1 | |
| SCHEMBL20740170 | 0.72 | — | — | |
| SCHEMBL20748902 | 0.68 | PDE4D (0.39) | PLATPDE4DCYP1A2PDE4BMAPK1 | |
| SCHEMBL23883533 | 0.66 | PDE4D (0.47) | PLATPDE4DCYP1A2PDE4BMAPK1 | |
| SCHEMBL26099994 | 0.65 | PDE4D (0.43) | PLATPDE4DPDE4BMAPK1SMN1; SMN2 | |
| SCHEMBL20748971 | 0.65 | PLAT (0.39) | PLATPDE4DCYP1A2PDE4BMAPK1 | |
| SCHEMBL20748890 | 0.64 | PLAT (0.39) | PLATPDE4DPDE4BMAPK1SMN1; SMN2 | |
| SCHEMBL22286136 | 0.64 | MAPK1 (0.50) | PLATPDE4DPDE4BMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068785-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-06-26 | — | — | EP | disclosed |
| EP-3068784-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-02-20 | — | — | EP | disclosed |