Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16700326 | 0.75 | ADORA1 (0.39) | PDE4DCYP1A2ADORA1HPGDSMN1; SMN2 | |
| SCHEMBL16699535 | 0.73 | PDE4D (0.35) | PDE4DCYP1A2HPGDLMNASMN1; SMN2 | |
| SCHEMBL16708910 | 0.72 | ALDH1A1 (0.44) | HPGDLMNASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL16700126 | 0.71 | PDE4D (0.33) | PDE4DCYP1A2HPGDSMN1; SMN2KMT2A | |
| SCHEMBL16699886 | 0.70 | KMT2A (0.35) | PDE4DCYP1A2KMT2AALDH1A1MAPT | |
| SCHEMBL16699032 | 0.67 | ADORA3 (0.37) | PDE4DCYP1A2HPGDKMT2AALDH1A1 | |
| SCHEMBL16700047 | 0.66 | PDE4D (0.33) | PDE4DCYP1A2LMNAMAPT | |
| SCHEMBL16701127 | 0.66 | ALDH1A1 (0.31) | ALDH1A1GAA | |
| SCHEMBL16699234 | 0.65 | ADORA1 (0.48) | ADORA1HPGDLMNASMN1; SMN2KMT2A | |
| SCHEMBL16699704 | 0.64 | CYP1A2 (0.36) | PDE4DCYP1A2HPGDSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068785-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-06-26 | — | — | EP | disclosed |
| EP-3068784-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-02-20 | — | — | EP | disclosed |