Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 17/20 | 0.40 |
| ▸ | DRD1 | P21728 | 12/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24199399 | 0.90 | DRD2 (0.41) | DRD2DRD1DRD4HRH4 | |
| SCHEMBL23125443 | 0.90 | DRD2 (0.41) | DRD2DRD1DRD4HRH4MEN1 | |
| SCHEMBL15047809 | 0.89 | DRD2 (0.40) | DRD2DRD1DRD4HRH4MEN1 | |
| SCHEMBL24199398 | 0.88 | DRD2 (0.40) | DRD2DRD1DRD4HRH4MEN1 | |
| SCHEMBL23125445 | 0.87 | DRD2 (0.44) | DRD2DRD1HRH4MEN1ABCB11 | |
| SCHEMBL20751621 | 0.85 | DRD2 (0.38) | DRD2DRD1DRD4HRH4 | |
| SCHEMBL20751562 | 0.84 | DRD2 (0.38) | DRD2DRD1DRD4HRH4 | |
| SCHEMBL23125441 | 0.80 | DRD1 (0.40) | DRD2DRD1DRD4HRH4MEN1 | |
| SCHEMBL15047808 | 0.80 | DRD2 (0.39) | DRD2DRD1DRD4HRH4 | |
| SCHEMBL20751674 | 0.78 | DRD1 (0.38) | DRD2DRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2790734-B1 | PRODRUGS OF SECONDARY AMINE COMPOUNDS | ALKERMES PHARMA IRELAND LTD (IE) | 2019-02-20 | — | — | EP | disclosed |