Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.65 |
| ▸ | JAK2 | O60674 | 2/20 | 0.65 |
| ▸ | SYK | P43405 | 4/20 | 0.64 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | CTSC | P53634 | 3/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20752296 | 0.86 | SYK (0.65) | LRRK2JAK2SYKCDC7MAOB | |
| SCHEMBL15584696 | 0.85 | SYK (0.64) | LRRK2JAK2SYKCDC7MAOB | |
| SCHEMBL19676195 | 0.83 | SYK (0.61) | LRRK2JAK2SYKCDC7MAOB | |
| SCHEMBL20752139 | 0.83 | SYK (0.61) | LRRK2JAK2SYKCDC7MAOB | |
| SCHEMBL20752320 | 0.82 | SYK (0.63) | LRRK2SYK | |
| SCHEMBL5416339 | 0.80 | SYK (0.58) | SYKCDC7MAOBGRM5JAK1 | |
| SCHEMBL1036294 | 0.80 | ALK (0.68) | LRRK2SYKMAPK9MAPK10 | |
| SCHEMBL28477252 | 0.79 | SYK (0.55) | SYKCDC7ABCG2CTSCZAP70 | |
| SCHEMBL20752170 | 0.79 | LRRK2 (0.56) | LRRK2JAK2SYKCDK2 | |
| SCHEMBL655532 | 0.78 | SYK (1.00) | JAK2SYKCDC7JAK3IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928891-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2019-02-20 | — | — | EP | disclosed |