Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.56 |
| ▸ | JAK2 | O60674 | 2/20 | 0.56 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.50 |
| ▸ | STK17B | O94768 | 2/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CCNK | O75909 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20752249 | 0.89 | AURKA (0.54) | LRRK2SYKAURKACCNA2CDK2 | |
| SCHEMBL20752236 | 0.85 | SYK (0.54) | LRRK2SYKAURKA | |
| SCHEMBL20752221 | 0.83 | SYK (0.44) | LRRK2STK17ASYKAURKACCNA2 | |
| SCHEMBL20752317 | 0.83 | LRRK2 (0.54) | LRRK2SYKEGFRERBB2 | |
| SCHEMBL20752204 | 0.83 | LRRK2 (0.51) | LRRK2JAK2SYKAURKA | |
| SCHEMBL20752164 | 0.82 | LRRK2 (0.67) | LRRK2 | |
| SCHEMBL20752146 | 0.79 | LRRK2 (0.65) | LRRK2JAK2SYKCDK2 | |
| SCHEMBL3495670 | 0.79 | JAK1 (0.44) | JAK2STK17ASTK17BAURKA | |
| SCHEMBL21658531 | 0.77 | LRRK2 (0.75) | LRRK2JAK2STK17ASTK17BAURKA | |
| SCHEMBL20752171 | 0.76 | AURKA (0.48) | SYKAURKACDK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928891-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2019-02-20 | — | — | EP | disclosed |