Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 2/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20752236 | 0.89 | SYK (0.54) | AURKASYKLRRK2CDK1 | |
| SCHEMBL20752170 | 0.89 | LRRK2 (0.56) | AURKASYKLRRK2CCNA2CDK2 | |
| SCHEMBL20752317 | 0.87 | LRRK2 (0.54) | SYKLRRK2 | |
| SCHEMBL20752221 | 0.87 | SYK (0.44) | AURKASYKLRRK2CCNT1CCNA2 | |
| SCHEMBL20752164 | 0.86 | LRRK2 (0.67) | LRRK2CYP1A2 | |
| SCHEMBL20752184 | 0.82 | SYK (0.55) | AURKASYKLRRK2CCNT1CCNA2 | |
| SCHEMBL20752089 | 0.80 | SYK (0.43) | AURKASYKLRRK2CCNT1CCNA2 | |
| SCHEMBL20752171 | 0.79 | AURKA (0.48) | AURKASYKCDK2KDRCYP1A2 | |
| SCHEMBL12224497 | 0.79 | SLC2A1 (0.67) | AURKASYKLRRK2CDK2KDR | |
| SCHEMBL4766530 | 0.77 | AURKA (0.55) | AURKASYKLRRK2CCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928891-B1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2019-02-20 | — | — | EP | disclosed |