Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 9/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.53 |
| ▸ | CDK9 | P50750 | 3/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.53 |
| ▸ | CDK1 | P06493 | 7/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | CCNH | P51946 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 3/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774317 | 0.88 | AURKA (0.53) | AURKACDK2CCNA2CCNT1CDK9 | |
| SCHEMBL4766065 | 0.85 | AURKA (0.50) | AURKACDK2CCNA2CCNT1CDK9 | |
| SCHEMBL4764044 | 0.85 | SYK (0.66) | AURKACDK2SYKLRRK2JAK1 | |
| SCHEMBL4772582 | 0.84 | AURKA (0.52) | AURKACDK2CCNA2CCNT1CDK9 | |
| SCHEMBL4766388 | 0.84 | AURKA (0.49) | AURKACDK2CCNA2CCNT1CDK9 | |
| SCHEMBL4769260 | 0.83 | CA2 (0.48) | AURKACDK2CCNA2CCNT1CDK9 | |
| SCHEMBL4774057 | 0.82 | PRKCQ (0.56) | AURKACDK2CDK1SYKLRRK2 | |
| SCHEMBL4772627 | 0.79 | CDK2 (0.51) | AURKACDK2CCNA2CCNT1CDK9 | |
| SCHEMBL4763589 | 0.79 | AURKA (0.51) | AURKACDK2CCNA2CCNT1CDK9 | |
| SCHEMBL4768983 | 0.78 | AURKA (0.53) | AURKACDK2CCNA2CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |