SCHEMBL20754136

SCHEMBL20754136

Clc1ccc2c(c1)sc1c(-c3nc(-c4ccccc4)nc(-c4ccccc4)n3)cccc12

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.40
MAPK1 P28482 1/20 0.40
HTT P42858 1/20 0.40
RAB9A P51151 1/20 0.40
ALOX5 P09917 1/20 0.40
PDE5A O76074 4/20 0.40
ABCG2 Q9UNQ0 4/20 0.40
TOP1 P11387 1/20 0.38
TOP2A P11388 1/20 0.38
NR1I3 Q14994 1/20 0.38
HRH4 Q9H3N8 1/20 0.38
LIMK1 P53667 1/20 0.38
CYP1A1 P04798 2/20 0.36
CYP1A2 P05177 2/20 0.36
CYP1B1 Q16678 2/20 0.36
ADORA2A P29274 1/20 0.35
ADORA1 P30542 1/20 0.35
PRKDC P78527 1/20 0.35
EGFR P00533 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22700419 0.97 ALOX5 (0.44) NPC1MAPK1HTTRAB9AALOX5
SCHEMBL22700615 0.90 TOP1 (0.35) NPC1MAPK1HTTRAB9AALOX5
SCHEMBL24151932 0.88 NR1I3 (0.45) MAPK1ALOX5PDE5AABCG2NR1I3
SCHEMBL22274501 0.88 ALOX5 (0.47) NPC1RAB9AALOX5PDE5AABCG2
SCHEMBL22329392 0.88 ALOX5 (0.46) MAPK1ALOX5LIMK1CYP1A1CYP1B1
SCHEMBL31643199 0.87 ALOX5 (0.44) NPC1MAPK1HTTRAB9AALOX5
SCHEMBL24216629 0.86 LIMK1 (0.45) MAPK1ALOX5LIMK1ADORA2AADORA1
SCHEMBL22329620 0.86 LIMK1 (0.45) MAPK1ALOX5LIMK1ADORA2AADORA1
SCHEMBL24216660 0.86 LIMK1 (0.45) MAPK1ALOX5LIMK1ADORA2AADORA1
SCHEMBL22329976 0.86 ALOX5 (0.45) MAPK1ALOX5LIMK1CYP1A1CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190058131-A1 ORGANIC LIGHT EMITTING DEVICE LG CHEM, LTD. (KR) 2019-02-21 US disclosed