Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.60 |
| ▸ | CDC42BPB | Q9Y5S2 | 11/20 | 0.60 |
| ▸ | CLK1 | P49759 | 5/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.45 |
| ▸ | JAK3 | P52333 | 3/20 | 0.43 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24672994 | 0.82 | ROCK2 (0.62) | ROCK2ROCK1CDC42BPBCLK1DYRK1A | |
| SCHEMBL29869562 | 0.75 | ROCK1 (1.00) | ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL24672681 | 0.75 | ROCK1 (1.00) | ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL24485904 | 0.68 | CCNK (0.42) | ROCK2ROCK1CDC42BPBJAK3CDC42BPA | |
| SCHEMBL24673179 | 0.68 | ROCK2 (1.00) | ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL29869448 | 0.68 | ROCK2 (1.00) | ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL20508755 | 0.68 | DYRK1A (0.52) | ROCK2ROCK1CDC42BPBCLK1DYRK1A | |
| SCHEMBL2693477 | 0.67 | PDGFRA (0.50) | CLK1DYRK1APIM1CLK4 | |
| SCHEMBL15652480 | 0.67 | MAPK1 (0.70) | ROCK2ROCK1CDC42BPBJAK3 | |
| SCHEMBL24672968 | 0.63 | ROCK1 (0.58) | ROCK2ROCK1CDC42BPBCDC42BPACDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019034890-A1 | PYRROLO[2,3-B]PYRIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2019-02-21 | — | — | WO | disclosed |