Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.62 |
| ▸ | CDC42BPB | Q9Y5S2 | 10/20 | 0.62 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | CDK9 | P50750 | 2/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.51 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | PRKCG | P05129 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24672968 | 0.83 | ROCK1 (0.58) | ROCK2ROCK1CDC42BPBCDK2CDK9 | |
| SCHEMBL20758388 | 0.82 | ROCK2 (0.60) | ROCK2ROCK1CDC42BPBCDK2CDC42BPA | |
| SCHEMBL20744209 | 0.80 | ROCK2 (0.60) | ROCK2ROCK1CDC42BPBCDK2CDK9 | |
| SCHEMBL30668720 | 0.80 | ROCK2 (0.60) | ROCK2ROCK1CDC42BPBCDK2CDK9 | |
| SCHEMBL24672681 | 0.77 | ROCK1 (1.00) | ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL29869562 | 0.77 | ROCK1 (1.00) | ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL24672937 | 0.76 | ROCK1 (0.57) | ROCK2ROCK1CDC42BPBCDK2CDK9 | |
| SCHEMBL20758425 | 0.75 | CDK2 (0.57) | ROCK2ROCK1CDC42BPBCDK2CDK9 | |
| SCHEMBL20744032 | 0.74 | ROCK2 (0.60) | ROCK2ROCK1CDC42BPBCDK2CDK9 | |
| SCHEMBL30668710 | 0.74 | ROCK2 (0.60) | ROCK2ROCK1CDC42BPBCDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11447505-B1 | Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2022-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447505-B1 | Pyrrolo[2,3-b]pyridine compounds and their use in the treatment of cancer | PDXK, CCNK, CDC42BPB | ROCK2 1115/4885ROCK1 1054/4885CDC42BPB 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.