Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19062105 | 0.78 | MAPT (0.47) | ALDH1A1KDM4EMAPTNISCHNPC1 | |
| SCHEMBL22137418 | 0.77 | KDM4E (0.39) | ALDH1A1HSD17B10KDM4EGAAMAPT | |
| SCHEMBL31149 | 0.75 | KMT2A (0.49) | ALDH1A1HSD17B10KDM4EGAAMAPT | |
| SCHEMBL88894 | 0.74 | GAA (0.55) | ALDH1A1HSD17B10GAAMAPTNISCH | |
| SCHEMBL871099 | 0.74 | GAA (0.55) | ALDH1A1HSD17B10GAAMAPTNISCH | |
| SCHEMBL56313 | 0.74 | GAA (0.55) | ALDH1A1HSD17B10GAAMAPTNISCH | |
| SCHEMBL8942627 | 0.74 | GAA (0.55) | ALDH1A1HSD17B10GAAMAPTNISCH | |
| Hydrochloric Acid SCHEMBL27373511 | 0.72 | GAA (0.53) | ALDH1A1HSD17B10GAAMAPTNISCH | |
| SCHEMBL20953362 | 0.71 | MAPT (0.38) | ALDH1A1KDM4EMAPTNISCHNPC1 | |
| SCHEMBL20953374 | 0.71 | MAPT (0.38) | ALDH1A1KDM4EMAPTNISCHNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200255421-A1 | TETRAHYDROPROTOBERBERINE COMPOUND, PREPARATION METHOD THEREFOR AND USES THEREOF, AND PHARMACEUTICAL COMPOSITION | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2020-08-13 | — | — | US | disclosed |
| EP-3670511-A1 | TETRAHYDROPROTOBERBERINE COMPOUND, PREPARATION METHOD THEREFOR AND USES THEREOF, AND PHARMACEUTICAL COMPOSITION | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2020-06-24 | — | — | EP | disclosed |
| WO-2019034031-A1 | TETRAHYDROPROTOBERBERINE COMPOUND, PREPARATION METHOD THEREFOR AND USES THEREOF, AND PHARMACEUTICAL COMPOSITION | 中国科学院上海药物研究所 | 2019-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255421-A1 | TETRAHYDROPROTOBERBERINE COMPOUND, PREPARATION METHOD THEREFOR AND USES THEREOF, AND PHARMACEUTICAL COMPOSITION | NOTUM, BHMT, CYP4F11 | ALDH1A1 446/4885HSD17B10 490/4885KDM4E 4709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.