SCHEMBL207609

SCHEMBL207609

C1=CC2=CC=NCN2C=C1

nearest known ligand 0.30

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
POLB P06746 1/20 0.30
HPGD P15428 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL443511 0.70
SCHEMBL17527498 0.67
Hydrochloric Acid SCHEMBL30153676 0.67
SCHEMBL168677 0.65
SCHEMBL27815530 0.64
SCHEMBL7604374 0.62 KDM4E (0.33) KDM4EALDH1A1POLBHPGDHSD17B10
SCHEMBL4552679 0.62 KDM4E (0.30) KDM4EALDH1A1HPGD
SCHEMBL17261368 0.62 KDM4E (0.30) KDM4EALDH1A1HPGD
SCHEMBL1382217 0.62
SCHEMBL1638013 0.62 KDM4E (0.30) KDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7935824-B2 Ethylenediamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2011-05-03 US claimed
US-20230147616-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-05-11 US disclosed
CN-115960139-A Organic electroluminescent material and device 环球展览公司 2023-04-14 CN disclosed
EP-1925611-B1 OPTICALLY ACTIVE DIAMINE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME DAIICHI SANKYO CO LTD (JP) 2016-04-13 EP disclosed
US-20120295965-A1 FUSED THIOPHENES AS DUAL INHIBITORS OF EGFR/VEGFR AND THEIR USE IN THE TREATMENT OF CANCER CORNING INCORPORATED 2012-11-22 US disclosed
EP-1577301-B1 Antithrombotic diaminocyclohexane derivatives DAIICHI SANKYO CO LTD (JP) 2012-09-12 EP disclosed
US-8148089-B2 Alpha-synuclein kinase ELAN PHARMA INTERNATIONAL LIMITED (IE) 2012-04-03 US disclosed
EP-2431370-A1 Monoacylated 1,2-diaminocycloalkanes DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2012-03-21 EP disclosed
US-8088796-B2 Triamine derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2012-01-03 US disclosed
US-20110312990-A1 Diamine Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2011-12-22 US disclosed
US-20040122063-A1 Ethylenediamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-06-24 US disclosed
EP-1415992-A1 DIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-05-06 EP disclosed
US-20040086907-A1 Combi-molecules having signal transduction inhibitory properties and dna damaging properties QIU, QIYU 2004-05-06 US disclosed
EP-1405852-A1 DIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-04-07 EP disclosed
EP-1395585-A1 ANTIBACTERIAL AGENTS Warner-Lambert Company LLC (US) 2004-03-10 EP disclosed
EP-1366027-A1 COMBI-MOLECULES HAVING SIGNAL TRANSDUCTION INHIBITORY PROPERTIES AND DNA DAMAGING PROPERTIES McGILL UNIVERSITY (CA) 2003-12-03 EP disclosed
US-20030114458-A1 Antibacterial agents WARNER-LAMBERT COMPANY 2003-06-19 US disclosed
EP-1270557-A1 ETHYLENEDIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2003-01-02 EP disclosed
WO-2002096908-A1 ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY LLC (US) 2002-12-05 WO disclosed
WO-2002068396-A1 COMBI-MOLECULES HAVING SIGNAL TRANSDUCTION INHIBITORY PROPERTIES AND DNA DAMAGING PROPERTIES MCGILL UNIVERSITY (CA) 2002-09-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030114458-A1 Antibacterial agents MRPL21, RPS6, RPS6KA1 KDM4E 2624/4885ALDH1A1 657/4885POLB 2454/4885
US-20230147616-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD2, OCIAD1, ICOSLG KDM4E 2824/4885ALDH1A1 1283/4885POLB 2059/4885
US-20120295965-A1 FUSED THIOPHENES AS DUAL INHIBITORS OF EGFR/VEGFR AND THEIR USE IN THE TREATMENT OF CANCER EGFR, ERBB2, KDR KDM4E 2746/4885ALDH1A1 3225/4885POLB 2938/4885
US-20110312990-A1 Diamine Derivatives C9, C1S, C1R KDM4E 3759/4885ALDH1A1 3734/4885POLB 1011/4885
US-20040086907-A1 Combi-molecules having signal transduction inhibitory properties and dna damaging properties EGFR, PCNA, ERCC2 KDM4E 4259/4885ALDH1A1 2925/4885POLB 20/4885
US-20040122063-A1 Ethylenediamine derivatives ECE1, F2, ECE2 KDM4E 645/4885ALDH1A1 2109/4885POLB 2014/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.