Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4342553 | 0.79 | NPC1 (0.34) | CTSANPC1RAB9A | |
| SCHEMBL21962291 | 0.73 | CA2 (0.35) | — | |
| SCHEMBL2078456 | 0.73 | — | — | |
| SCHEMBL2078460 | 0.73 | — | — | |
| SCHEMBL21962093 | 0.72 | CTSA (0.32) | CTSANPC1RAB9A | |
| SCHEMBL2077245 | 0.70 | — | — | |
| SCHEMBL2077248 | 0.70 | — | — | |
| SCHEMBL4342560 | 0.68 | CTSA (0.32) | CTSALMNANPC1RAB9A | |
| SCHEMBL2078473 | 0.68 | TBXAS1 (0.33) | RAB9A | |
| SCHEMBL2078476 | 0.68 | TBXAS1 (0.33) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163909-B2 | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2012-04-24 | — | — | US | disclosed |