Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20765612 | 0.85 | ALDH1A1 (0.56) | KDM4ELMNAALDH1A1MEN1KMT2A | |
| SCHEMBL20765451 | 0.85 | CYP2D6 (0.54) | KDM4EALDH1A1HTTMAPTDRD2 | |
| SCHEMBL20765671 | 0.84 | ALDH1A1 (0.51) | KDM4ELMNAALDH1A1MEN1KMT2A | |
| SCHEMBL20765593 | 0.83 | KDM4E (0.48) | KDM4ELMNAALDH1A1MEN1KMT2A | |
| SCHEMBL20774925 | 0.82 | ALDH1A1 (0.52) | KDM4ELMNAALDH1A1MEN1KMT2A | |
| SCHEMBL20782579 | 0.81 | ALDH1A1 (0.55) | KDM4ELMNAALDH1A1MEN1KMT2A | |
| SCHEMBL20765518 | 0.80 | KDM4E (0.47) | KDM4ELMNAALDH1A1MEN1KMT2A | |
| SCHEMBL20765539 | 0.80 | CHEK2 (0.45) | KDM4ELMNAALDH1A1MEN1KMT2A | |
| SCHEMBL20765631 | 0.78 | ALDH1A1 (0.52) | KDM4ELMNAALDH1A1MEN1KMT2A | |
| SCHEMBL20782400 | 0.76 | KDM4E (0.59) | KDM4ELMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019038683-A1 | COMPOUNDS TARGETING TANDEM BRCT DOMAINS OF BRCA1, COMPOSITIONS AND METHODS THEREOF | INSTITUTE FOR STEM CELL BIOLOGY AND REGENERATIVE MEDICINE (IN) | 2019-02-28 | — | — | WO | claimed |