SCHEMBL2076685

SCHEMBL2076685

c1ccc(P(c2ccccc2)c2ccc3c(c2-c2c(P(c4ccccc4)c4ccccc4)ccc4c2OCO4)OCO3)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 1/20 0.39
CYP3A4 P08684 2/20 0.37
TDP1 Q9NUW8 1/20 0.37
TXNRD1 Q16881 1/20 0.36
TXNRD3 Q86VQ6 1/20 0.36
TXNRD2 Q9NNW7 1/20 0.36
CYP1A2 P05177 3/20 0.35
CYP1B1 Q16678 2/20 0.35
CYP1A1 P04798 1/20 0.35
DRD1 P21728 3/20 0.35
BAD Q92934 1/20 0.34
PTGS2 P35354 2/20 0.33
MAOB P27338 2/20 0.32
PKM P14618 1/20 0.32
TSHR P16473 1/20 0.32
DRD2 P14416 1/20 0.32
AOC3 Q16853 2/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C9 P11712 1/20 0.31
MAPK1 P28482 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27899 1.00 ABCG2 (0.39) ABCG2CYP3A4TDP1TXNRD1TXNRD3
SCHEMBL29352284 1.00 ABCG2 (0.39) ABCG2CYP3A4TDP1TXNRD1TXNRD3
SCHEMBL6904608 0.98 ABCG2 (0.38) ABCG2CYP3A4TDP1TXNRD1TXNRD3
SCHEMBL16449681 0.91 NQO2 (0.34) ABCG2CYP3A4TDP1TXNRD1TXNRD3
Acetic Acid SCHEMBL29761322 0.91 NPC1 (0.35) CYP3A4TDP1TXNRD1TXNRD3TXNRD2
SCHEMBL17758851 0.89 DRD1 (0.32) ABCG2TXNRD1TXNRD3TXNRD2CYP1A2
SCHEMBL13695077 0.89 AOC3 (0.37) ABCG2TDP1TXNRD1TXNRD3TXNRD2
SCHEMBL29365010 0.86 ITGB2 (0.39) CYP3A4TDP1DRD1MAOBPKM
SCHEMBL1203836 0.86 ITGB2 (0.39) CYP3A4TDP1DRD1MAOBPKM
SCHEMBL5684662 0.85 ABCG2 (0.38) ABCG2CYP3A4TDP1TXNRD1TXNRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2123357-B1 CYANATION CATALYST AND METHOD FOR PRODUCING OPTICALLY ACTIVE CYANHYDRIN COMPOUND USING THE SAME UNIV HOKKAIDO NAT UNIV CORP (JP) 2013-04-17 EP disclosed
US-8163947-B2 Cyanation catalyst and method for producing optically active cyanhydrin compound using the same NATIONAL UNIVERSITY CORPORATION, HOKKAIDO UNIVERSITY (JP) 2012-04-24 US disclosed
US-20100029977-A1 CYANATION CATALYST AND METHOD FOR PRODUCING OPTICALLY ACTIVE CYANHYDRIN COMPOUND USING THE SAME NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) 2010-02-04 US disclosed
EP-2123357-A1 CYANATION CATALYST AND METHOD FOR PRODUCING OPTICALLY ACTIVE CYANHYDRIN COMPOUND USING THE SAME National University Corporation Hokkaido University (JP) 2009-11-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100029977-A1 CYANATION CATALYST AND METHOD FOR PRODUCING OPTICALLY ACTIVE CYANHYDRIN COMPOUND USING THE SAME TYR, IK, CYB5R3 ABCG2 848/4885CYP3A4 217/4885TDP1 4152/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.