Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 1/20 | 0.59 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.59 |
| ▸ | MC4R | P32245 | 9/20 | 0.46 |
| ▸ | MC3R | P41968 | 8/20 | 0.46 |
| ▸ | MC5R | P33032 | 7/20 | 0.46 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL759516 | 0.93 | CCR6 (0.66) | CCR6PAX8MC4RMC3RMC5R | |
| SCHEMBL7535687 | 0.92 | CCR6 (0.64) | CCR6PAX8MC4RMC3RMC5R | |
| SCHEMBL15355992 | 0.86 | CCR6 (0.59) | CCR6PAX8TDP1 | |
| SCHEMBL10181395 | 0.86 | CCR6 (0.61) | CCR6PAX8MC4RMC3RMC5R | |
| SCHEMBL17377997 | 0.86 | CCR6 (0.61) | CCR6PAX8MC4RMC3RMC5R | |
| SCHEMBL2584582 | 0.85 | LIMK2 (0.56) | MC4RMC3RMC5RLIMK2KMT2A | |
| SCHEMBL4704081 | 0.84 | CCR6 (0.60) | CCR6PAX8 | |
| SCHEMBL4890818 | 0.84 | CCR6 (0.59) | CCR6PAX8MC4RMC3RMC5R | |
| SCHEMBL4705691 | 0.83 | CCR6 (0.62) | CCR6PAX8SLC6A2SLC6A3KMT2A | |
| SCHEMBL3795459 | 0.82 | MC4R (0.61) | MC4RMC3RMC5RLIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216989-B2 | (Poly) aminoacetamide derivatives of epipodophyllotoxin their process of preparation and their applications in therapeutics as anticancer agents | PIERRE FABRE MEDICAMENT (FR) | 2015-12-22 | — | — | US | disclosed |
| US-20110053967-A1 | (POLY) AMINOACETAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN THEIR PROCESS OF PREPARATION AND THEIR APPLICATIONS IN THERAPEUTICS AS ANTICANCER AGENTS | IMBERT THIERRY | 2011-03-03 | — | — | US | disclosed |
| US-7846926-B2 | (Poly)aminoacetamide derivatives of epipodophyllotoxin their process of preparation and their applications in therapeutics as anticancer agents | PIERRE FABRE MEDICAMENT (FR) | 2010-12-07 | — | — | US | disclosed |
| CN-1946727-B | (Poly) aminoacetamide derivatives of epipodophyllotoxin, their process of preparation and their applications in therapeutics as anticancer agents | PF MEDICAMENT | 2010-08-11 | — | — | CN | disclosed |
| US-20090170843-A1 | (Poly) aminoacetamide derivatives of epipodophyllotoxin their process of preparation and their applications in therapeutics as anticancer agents | PIERRE FABRE MEDICAMENT (FR) | 2009-07-02 | — | — | US | disclosed |
| CN-1946727-A | (Poly) aminoacetamide derivatives of epipodophyllotoxin their process of preparation and their applications in therapeutics as anticancer agents | PF MEDICAMENT (FR) | 2007-04-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053967-A1 | (POLY) AMINOACETAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN THEIR PROCESS OF PREPARATION AND THEIR APPLICATIONS IN THERAPEUTICS AS ANTICANCER AGENTS | NPEPPS, PTMA, PARN | CCR6 2465/4885PAX8 1413/4885MC4R 3929/4885 |
| US-20090170843-A1 | (Poly) aminoacetamide derivatives of epipodophyllotoxin their process of preparation and their applications in therapeutics as anticancer agents | NPEPPS, PTMA, PARN | CCR6 2465/4885PAX8 1413/4885MC4R 3929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.