Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | MITF | O75030 | 1/20 | 0.67 |
| ▸ | CNR1 | P21554 | 1/20 | 0.67 |
| ▸ | CNR2 | P34972 | 1/20 | 0.67 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.67 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.67 |
| ▸ | XBP1 | P17861 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808661 | 0.94 | HTT (0.61) | LMNAMAPK1MITFCNR1CNR2 | |
| SCHEMBL121529 | 0.89 | CHRM2 (0.70) | HTTCHRM2GAAPOLBKDM4E | |
| Hydrochloric Acid SCHEMBL9479560 | 0.87 | CHRM2 (0.68) | HTTCHRM2GAAPOLBKDM4E | |
| Hydrochloric Acid SCHEMBL2147064 | 0.87 | CHRM2 (0.68) | HTTCHRM2GAAPOLBKDM4E | |
| SCHEMBL19041058 | 0.84 | HTT (0.51) | LMNAMAPK1MITFCNR1CNR2 | |
| SCHEMBL22305119 | 0.83 | CHRM2 (0.63) | HTTCHRM2GAAPOLBKDM4E | |
| SCHEMBL1796909 | 0.82 | LMNA (0.77) | LMNAMAPK1CHRM2MEN1KMT2A | |
| SCHEMBL184001 | 0.82 | LMNA (0.77) | LMNAMAPK1CHRM2MEN1KMT2A | |
| SCHEMBL20781096 | 0.82 | MAPK1 (0.50) | LMNAMAPK1MITFCNR1CNR2 | |
| SCHEMBL6418283 | 0.82 | APLNR (0.73) | LMNAMAPK1MITFCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019040105-A2 | COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES | ACADIA PHARMACEUTICALS INC. (US) | 2019-02-28 | — | — | WO | disclosed |
| WO-2019040105-A2 | COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES | ACADIA PHARMACEUTICALS INC. (US) | 2019-02-28 | — | — | WO | disclosed |