SCHEMBL20767249

SCHEMBL20767249

COc1ccc(CN(Cc2ccc(F)cc2)C(=O)CC2CCN(C)CC2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 8/20 0.52
OPRM1 P35372 2/20 0.51
TAS2R14 Q9NYV8 1/20 0.45
CHRM1 P11229 2/20 0.45
CHRM5 P08912 1/20 0.45
CHRM3 P20309 1/20 0.45
KCNH2 Q12809 2/20 0.45
ABCB11 O95342 1/20 0.45
CYP1A2 P05177 1/20 0.45
ADRB2 P07550 1/20 0.45
CHRM2 P08172 1/20 0.45
DRD1 P21728 1/20 0.45
TBXA2R P21731 1/20 0.45
SLC6A2 P23975 1/20 0.45
HTR2C P28335 1/20 0.45
GPR183 P32249 1/20 0.45
CYP2C19 P33261 1/20 0.45
ADRA1A P35348 1/20 0.45
APLNR P35414 1/20 0.45
DRD3 P35462 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20767191 0.94 HTR2A (0.57) HTR2AOPRM1CHRM1CHRM5CHRM3
SCHEMBL20766869 0.92 HTR2A (0.50) HTR2AOPRM1CHRM1CHRM5CHRM3
SCHEMBL20766920 0.90 HTR2A (0.56) HTR2AOPRM1CHRM1KCNH2ABCB11
SCHEMBL20767243 0.85 ALDH1A1 (0.46) HTR2AOPRM1TAS2R14CHRM1CHRM3
SCHEMBL20766914 0.84 HTR2A (0.54) HTR2AOPRM1TAS2R14CHRM1CHRM5
SCHEMBL20767195 0.81 HTR2A (0.76) HTR2AOPRM1CHRM1KCNH2ABCB11
SCHEMBL20767250 0.81 HTR2A (0.67) HTR2A
SCHEMBL20767208 0.80 HTR2A (0.52) HTR2AOPRM1SMN1; SMN2
SCHEMBL342474 0.79 HTR2A (0.64) HTR2AOPRM1CHRM1KCNH2ABCB11
SCHEMBL340689 0.79 HTR2A (0.64) HTR2AOPRM1CHRM1KCNH2ABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019040105-A2 COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES ACADIA PHARMACEUTICALS INC. (US) 2019-02-28 WO claimed
WO-2019040105-A2 COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES ACADIA PHARMACEUTICALS INC. (US) 2019-02-28 WO disclosed
WO-2019040105-A2 COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES ACADIA PHARMACEUTICALS INC. (US) 2019-02-28 WO disclosed