SCHEMBL20767412

SCHEMBL20767412

CCOP(=O)(OCC)Oc1ccccc1-c1cc(=O)[nH]c2c(-c3ccc(Cl)c(Cl)c3)c(C(F)(F)F)nn12

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ARF6 P62330 19/20 0.65
PLAT P00750 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20767279 0.88 ARF6 (0.74) ARF6PLAT
SCHEMBL20767271 0.79 ARF6 (1.00) ARF6
SCHEMBL22902196 0.76 ARF6 (1.00) ARF6
SCHEMBL20796208 0.75 ARF6 (0.82) ARF6
SCHEMBL20796201 0.75 ARF6 (1.00) ARF6PLAT
SCHEMBL20796209 0.74 ARF6 (0.81) ARF6PLAT
SCHEMBL20796512 0.72 ARF6 (0.81) ARF6
SCHEMBL20796517 0.71 ARF6 (1.00) ARF6PLAT
SCHEMBL20796514 0.71 ARF6 (0.83) ARF6
SCHEMBL20796487 0.70 ARF6 (1.00) ARF6PLAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11414442-B2 ARF6 inhibitors and related methods NAVIGEN, INC. (US) 2022-08-16 US disclosed
US-20210017201-A1 ARF6 INHIBITORS AND RELATED METHODS NAVIGEN, INC. 2021-01-21 US disclosed
EP-3672597-A2 ARF6 INHIBITORS AND RELATED METHODS Navigen, Inc. (US) 2020-07-01 EP disclosed
WO-2019040499-A2 ARF6 INHIBITORS AND RELATED METHODS NAVIGEN, INC. (US) 2019-02-28 WO disclosed
WO-2019040499-A2 ARF6 INHIBITORS AND RELATED METHODS NAVIGEN, INC. (US) 2019-02-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210017201-A1 ARF6 INHIBITORS AND RELATED METHODS ARF6, ARF1, ARF5 ARF6 1/4885PLAT 621/4885
US-11414442-B2 ARF6 inhibitors and related methods ARF6, ARF1, ARF5 ARF6 1/4885PLAT 621/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.