Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 3/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.33 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29627968 | 0.85 | ROCK2 (0.44) | ADORA2AROCK2ROCK1NAMPTHCRTR1 | |
| SCHEMBL20769711 | 0.85 | ROCK2 (0.44) | ADORA2AROCK2ROCK1NAMPTHCRTR1 | |
| SCHEMBL22229600 | 0.78 | ROCK2 (0.39) | ADORA2AROCK2ROCK1NAMPTHCRTR1 | |
| SCHEMBL30189626 | 0.78 | ROCK2 (0.39) | ADORA2AROCK2ROCK1NAMPTHCRTR1 | |
| SCHEMBL22229605 | 0.76 | GRM4 (0.39) | ADORA2AROCK2ROCK1NAMPTHCRTR1 | |
| SCHEMBL30189725 | 0.76 | GRM4 (0.39) | ADORA2AROCK2ROCK1NAMPTHCRTR1 | |
| SCHEMBL29627865 | 0.76 | ROCK2 (0.44) | ADORA2AROCK2ROCK1NAMPTHCRTR1 | |
| SCHEMBL20769692 | 0.75 | MEN1 (0.37) | HCRTR1HCRTR2MEN1NPC1RAB9A | |
| SCHEMBL29627931 | 0.74 | TRPV1 (0.39) | ADORA2AROCK2ROCK1NAMPTFAAH | |
| SCHEMBL22242874 | 0.72 | ROCK1 (0.46) | ADORA2AROCK2ROCK1NAMPTSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11542256-B2 | Vinylheterocycles as Rho-associated coiled-coil kinase (ROCK) inhibitors | ANGION BIOMEDICA CORP. (US) | 2023-01-03 | — | — | US | disclosed |
| US-11542256-B2 | Vinylheterocycles as Rho-associated coiled-coil kinase (ROCK) inhibitors | ANGION BIOMEDICA CORP. (US) | 2023-01-03 | — | — | US | disclosed |
| US-20200231576-A1 | VINYLHETEROCYCLES AS RHO-ASSOCIATED COILED-COIL KINASE (ROCK) INHIBITORS | ANGION BIOMEDICA CORP. | 2020-07-23 | — | — | US | disclosed |
| US-20200231576-A1 | VINYLHETEROCYCLES AS RHO-ASSOCIATED COILED-COIL KINASE (ROCK) INHIBITORS | ANGION BIOMEDICA CORP. | 2020-07-23 | — | — | US | disclosed |
| CN-111406051-A | Vinylheterocycles as RHO-associated coiled coil kinase (ROCK) inhibitors | 安吉昂生物医药公司 | 2020-07-10 | — | — | CN | disclosed |
| EP-3676262-A1 | VINYLHETEROCYCLES AS RHO-ASSOCIATED COILED-COIL KINASE (ROCK) INHIBITORS | Angion Biomedica Corp. (US) | 2020-07-08 | — | — | EP | disclosed |
| WO-2019046795-A1 | VINYLHETEROCYCLES AS RHO-ASSOCIATED COILED-COIL KINASE (ROCK) INHIBITORS | ANGION BIOMEDICA CORP. (US) | 2019-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200231576-A1 | VINYLHETEROCYCLES AS RHO-ASSOCIATED COILED-COIL KINASE (ROCK) INHIBITORS | ROCK1, ROCK2, RHOT2 | ADORA2A 2557/4885ROCK2 2/4885ROCK1 1/4885 |
| US-11542256-B2 | Vinylheterocycles as Rho-associated coiled-coil kinase (ROCK) inhibitors | ROCK1, ROCK2, RHOT2 | ADORA2A 2557/4885ROCK2 2/4885ROCK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.