Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20769671 | 0.99 | KCNH2 (0.45) | AKR1C3AKR1C2PTGDR2KCNH2AKR1C4 | |
| SCHEMBL20769661 | 0.79 | CNR1 (0.55) | AKR1C3AKR1C2AKR1C4PTGS1ALDH1A1 | |
| SCHEMBL20769734 | 0.77 | KCNA3 (0.46) | AKR1C3AKR1C2PTGDR2AKR1C4PTGS1 | |
| SCHEMBL840616 | 0.76 | PTGDR2 (0.75) | PTGDR2ALDH1A1KMT2A | |
| SCHEMBL24117805 | 0.75 | PTGDR2 (0.53) | PTGDR2KDM4EALDH1A1LMNAMEN1 | |
| SCHEMBL6242130 | 0.75 | KMT2A (0.52) | AKR1C3AKR1C2AKR1C4PTGS1KEAP1 | |
| SCHEMBL841162 | 0.75 | PTGDR2 (0.79) | PTGDR2 | |
| SCHEMBL20787964 | 0.74 | PTGDR2 (0.53) | PTGDR2KCNH2KDM4EALDH1A1LMNA | |
| SCHEMBL28977349 | 0.73 | AKR1C3 (0.58) | AKR1C3AKR1C2PTGDR2AKR1C4PTGS1 | |
| SCHEMBL20769670 | 0.73 | KCNH2 (0.59) | AKR1C3AKR1C2KCNH2AKR1C4PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |