Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 7/20 | 0.55 |
| ▸ | ICMT | O60725 | 8/20 | 0.53 |
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22439063 | 0.86 | ICMT (0.48) | CNR1ICMTCNR2TBXAS1 | |
| SCHEMBL20769671 | 0.81 | KCNH2 (0.45) | CNR1ALDH1A1LMNAAKR1C3AKR1C2 | |
| SCHEMBL20769715 | 0.79 | AKR1C3 (0.46) | CNR2ALDH1A1LMNAAKR1C3AKR1C2 | |
| SCHEMBL7682923 | 0.79 | ICMT (0.54) | CNR1ICMTCNR2TBXAS1 | |
| SCHEMBL20769719 | 0.77 | ALDH1A1 (0.65) | ICMTALDH1A1LMNAAKR1C3AKR1C2 | |
| SCHEMBL20787913 | 0.77 | CNR1 (0.55) | CNR1CNR2 | |
| SCHEMBL20769700 | 0.76 | LMNA (0.75) | ICMTCNR2ALDH1A1LMNAPPARG | |
| SCHEMBL28365671 | 0.76 | CDC25A (0.56) | CNR1ICMTCNR2ALDH1A1LMNA | |
| SCHEMBL2642840 | 0.76 | CNR1 (0.66) | CNR1CNR2 | |
| SCHEMBL20769701 | 0.75 | ICMT (0.57) | ICMTALDH1A1LMNAAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |