Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.46 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20787969 | 0.78 | KCNA3 (0.46) | KCNA3SLC5A2PTGDR2CNR2 | |
| SCHEMBL20787985 | 0.78 | KCNA3 (0.48) | KCNA3SLC5A2PTGDR2CNR2NPSR1 | |
| SCHEMBL20769715 | 0.77 | AKR1C3 (0.46) | SLC5A2PTGDR2ALDH1A1LMNACNR2 | |
| SCHEMBL20769671 | 0.76 | KCNH2 (0.45) | SLC5A2PTGDR2ALDH1A1LMNAAKR1C3 | |
| SCHEMBL20769700 | 0.69 | LMNA (0.75) | ALDH1A1LMNACNR2MEN1KMT2A | |
| SCHEMBL20769675 | 0.69 | AKR1C3 (0.72) | ALDH1A1LMNAAKR1C3AKR1C2AKR1C4 | |
| SCHEMBL6242130 | 0.69 | KMT2A (0.52) | ALDH1A1LMNAAKR1C3AKR1C2KEAP1 | |
| SCHEMBL20769653 | 0.68 | ALDH1A1 (0.61) | ALDH1A1LMNAAKR1C3AKR1C2PPARG | |
| SCHEMBL20788555 | 0.68 | ALDH1A1 (0.46) | PTGDR2ALDH1A1LMNAAKR1C3AKR1C2 | |
| SCHEMBL20769657 | 0.67 | PLA2G4A (0.53) | ALDH1A1LMNAAKR1C3AKR1C2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |