Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20769695 | 0.85 | KMT2A (0.54) | ALDH1A1HPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20791843 | 0.82 | KMT2A (0.53) | ALDH1A1HPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20791836 | 0.79 | KMT2A (0.50) | ALDH1A1HPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20769713 | 0.75 | NPC1 (0.57) | ALDH1A1HPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20769703 | 0.74 | KEAP1 (0.48) | ALDH1A1HPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20769699 | 0.74 | KEAP1 (0.48) | ALDH1A1HPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20788554 | 0.74 | KEAP1 (0.47) | ALDH1A1HPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20769729 | 0.73 | KEAP1 (0.47) | ALDH1A1HPGDSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7437596 | 0.73 | KEAP1 (0.62) | MAPT | |
| SCHEMBL20769688 | 0.72 | KEAP1 (0.46) | ALDH1A1HPGDSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |