Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20769714 | 0.86 | KMT2A (0.51) | KMT2AMEN1LMNAHPGDHTT | |
| SCHEMBL20789125 | 0.83 | KMT2A (0.44) | KMT2AMEN1LMNAHPGDHTT | |
| SCHEMBL20769721 | 0.79 | ALDH1A1 (0.52) | KMT2AMEN1LMNAHPGDHTT | |
| SCHEMBL20769665 | 0.77 | KMT2A (0.44) | KMT2AMEN1LMNAHPGDHTT | |
| SCHEMBL77834 | 0.74 | KMT2A (0.77) | KMT2AMEN1LMNAHPGDHTT | |
| SCHEMBL24435435 | 0.69 | MEN1 (0.57) | KMT2AMEN1LMNAHPGDHTT | |
| SCHEMBL10078878 | 0.68 | KMT2A (1.00) | KMT2AMEN1LMNAHPGDHTT | |
| SCHEMBL20791843 | 0.68 | KMT2A (0.53) | KMT2AMEN1LMNAHPGDHTT | |
| SCHEMBL11357696 | 0.67 | HRH1 (0.49) | KMT2AMEN1LMNAHTTTSHR | |
| SCHEMBL20787988 | 0.67 | MEN1 (0.54) | KMT2AMEN1LMNAHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |