Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29644283 | 0.85 | MAP2K1 (0.57) | ADORA2AMAP2K1NR4A2MEN1KMT2A | |
| SCHEMBL26979129 | 0.85 | MAP2K1 (0.57) | ADORA2AMAP2K1NR4A2MEN1KMT2A | |
| SCHEMBL7024233 | 0.81 | ADORA2A (0.50) | ADORA2AMAP2K1NR4A2MEN1KMT2A | |
| SCHEMBL3554174 | 0.81 | ADORA2A (0.56) | ADORA2AMAP2K1MEN1KMT2AADORA1 | |
| SCHEMBL28089657 | 0.78 | ADORA2A (0.48) | ADORA2AMEN1KMT2AADORA1 | |
| SCHEMBL7025897 | 0.77 | ADORA2A (0.52) | ADORA2AMEN1KMT2AADORA1 | |
| SCHEMBL21588983 | 0.76 | TUBB1 (0.60) | ADORA2APIM1ROCK2ROCK1FGFR4 | |
| SCHEMBL4239387 | 0.76 | ADORA2A (0.48) | ADORA2AMAP2K1NR4A2MEN1KMT2A | |
| SCHEMBL1940550 | 0.75 | MAP2K1 (0.73) | ADORA2AMAP2K1KMT2AROCK1CLK1 | |
| SCHEMBL7099389 | 0.74 | ADORA2A (0.47) | ADORA2AMAP2K1MEN1KMT2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |