Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3554174 | 0.83 | ADORA2A (0.56) | ADORA2AADORA1MEN1KMT2AMAP2K1 | |
| SCHEMBL7024233 | 0.81 | ADORA2A (0.50) | ADORA2AADORA1MEN1KMT2AMAP2K1 | |
| SCHEMBL7025897 | 0.79 | ADORA2A (0.52) | ADORA2AADORA1MEN1KMT2AALDH1A1 | |
| SCHEMBL26979129 | 0.78 | MAP2K1 (0.57) | ADORA2AMEN1KMT2AMAP2K1NR4A2 | |
| SCHEMBL29644283 | 0.78 | MAP2K1 (0.57) | ADORA2AMEN1KMT2AMAP2K1NR4A2 | |
| SCHEMBL20769722 | 0.76 | ADORA2A (0.46) | ADORA2AADORA1MEN1KMT2AMAP2K1 | |
| SCHEMBL5122900 | 0.75 | MAP2K1 (0.61) | ADORA2AKMT2AMAP2K1 | |
| SCHEMBL28089657 | 0.75 | ADORA2A (0.48) | ADORA2AADORA1MEN1KMT2A | |
| SCHEMBL7099389 | 0.74 | ADORA2A (0.47) | ADORA2AADORA1MEN1KMT2AALDH1A1 | |
| SCHEMBL31368049 | 0.71 | JAK2 (0.46) | MAP2K1NR4A2PKMCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524706-B2 | 1,4-diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2013-09-03 | — | — | US | disclosed |
| EP-1575960-B1 | 1,4-DIAZABICYCLO 3.2.2 NONANECARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2009-03-18 | — | — | EP | disclosed |
| US-20090054416-A1 | 1,4-Diazabicyclo[3.2.2]nonanecarboxamide Derivatives, Preparation and Therapeutic Use Thereof | SANOFI-AVENTIS (FR) | 2009-02-26 | — | — | US | disclosed |
| US-7456171-B2 | 1,4-Diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2008-11-25 | — | — | US | disclosed |
| US-20050182062-A1 | 1,4-Diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054416-A1 | 1,4-Diazabicyclo[3.2.2]nonanecarboxamide Derivatives, Preparation and Therapeutic Use Thereof | CNR1, CNR2, CACNA1A | ADORA2A 45/4885ADORA1 35/4885MEN1 2436/4885 |
| US-20050182062-A1 | 1,4-Diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof | CNR1, CNR2, CBR3 | ADORA2A 246/4885ADORA1 121/4885MEN1 3032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.