Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.65 |
| ▸ | NPC1 | O15118 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | TMIGD3 | P0DMS9 | 4/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | STAT1 | P42224 | 1/20 | 0.60 |
| ▸ | CASP3 | P42574 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20787912 | 0.84 | NPC1 (0.60) | RAB9ANPC1ALDH1A1LMNANPSR1 | |
| SCHEMBL20769658 | 0.84 | RAB9A (0.60) | RAB9ANPC1ALDH1A1LMNANPSR1 | |
| SCHEMBL20769660 | 0.84 | NPC1 (0.55) | RAB9ANPC1ALDH1A1LMNANPSR1 | |
| SCHEMBL20791871 | 0.82 | NPC1 (0.63) | RAB9ANPC1ALDH1A1LMNANPSR1 | |
| SCHEMBL20788793 | 0.82 | NPC1 (0.58) | RAB9ANPC1ALDH1A1LMNANPSR1 | |
| SCHEMBL20791869 | 0.82 | NPC1 (0.65) | RAB9ANPC1ALDH1A1LMNANPSR1 | |
| SCHEMBL20769713 | 0.82 | NPC1 (0.57) | RAB9ANPC1ALDH1A1LMNANPSR1 | |
| SCHEMBL20769730 | 0.82 | NPC1 (0.58) | RAB9ANPC1ALDH1A1LMNANPSR1 | |
| SCHEMBL20769704 | 0.81 | NPC1 (0.56) | RAB9ANPC1ALDH1A1LMNANPSR1 | |
| SCHEMBL20769726 | 0.81 | NPC1 (0.56) | RAB9ANPC1ALDH1A1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |
| WO-2019046668-A1 | AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2019-03-07 | — | — | WO | disclosed |