Remacemide

Remacemide

SCHEMBL20769836

CC(Cc1ccccc1)(NC(=O)CN)c1ccccc1.CC(Cc1ccccc1)(NC(=O)CN)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 1.00
CYP3A4 P08684 2/20 1.00
RECQL P46063 1/20 1.00
MAPK1 P28482 1/20 0.97
CYP2C19 P33261 3/20 0.44
CYP2C9 P11712 2/20 0.44
ALDH1A1 P00352 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.42
HIF1A Q16665 1/20 0.42
SLC6A2 P23975 1/20 0.42
TAAR1 Q96RJ0 1/20 0.42
MMP2 P08253 1/20 0.41
AOC3 Q16853 2/20 0.40
LMNA P02545 1/20 0.40
CYP2D6 P10635 1/20 0.40
MAPT P10636 1/20 0.40
KMT2A Q03164 1/20 0.40
TSHR P16473 1/20 0.39
CTSC P53634 1/20 0.39
MMP8 P22894 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Remacemide SCHEMBL151148 1.00 CYP1A2 (1.00) CYP1A2CYP3A4RECQLMAPK1CYP2C19
Remacemide SCHEMBL635940 0.98 MAPK1 (1.00) CYP1A2CYP3A4RECQLMAPK1CYP2C19
Remacemide SCHEMBL31270066 0.93 CYP3A4 (0.86) CYP1A2CYP3A4RECQLMAPK1CYP2C19
Remacemide SCHEMBL7266326 0.93 CYP3A4 (0.86) CYP1A2CYP3A4RECQLMAPK1CYP2C19
Remacemide SCHEMBL7266094 0.93 CYP3A4 (0.86) CYP1A2CYP3A4RECQLMAPK1CYP2C19
SCHEMBL9054250 0.91 CYP3A4 (0.84) CYP1A2CYP3A4RECQLMAPK1CYP2C19
SCHEMBL5300822 0.91 CYP3A4 (0.84) CYP1A2CYP3A4RECQLMAPK1CYP2C19
SCHEMBL5300046 0.91 CYP3A4 (0.84) CYP1A2CYP3A4RECQLMAPK1CYP2C19
SCHEMBL5306622 0.90 CYP3A4 (0.82) CYP1A2CYP3A4RECQLMAPK1CYP2C19
SCHEMBL9513149 0.90 CYP1A2 (0.82) CYP1A2CYP3A4RECQLMAPK1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3675838-A1 LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS Puretecch LYT, Inc. (US) 2020-07-08 EP disclosed
WO-2019046491-A1 LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS ARIYA THERAPEUTICS, INC. (US) 2019-03-07 WO disclosed