Remacemide

Remacemide

SCHEMBL635940

CC(Cc1ccccc1)(NC(=O)CN)c1ccccc1.Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Remacemide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 known ✓ P23975 1/20 0.41
MMP8 known ✓ P22894 1/20 0.38
MAPK1 P28482 1/20 1.00
CYP1A2 P05177 3/20 0.97
CYP3A4 P08684 2/20 0.97
RECQL P46063 1/20 0.97
CYP2C19 P33261 3/20 0.43
CYP2C9 P11712 2/20 0.43
ALDH1A1 P00352 1/20 0.43
AOC3 Q16853 2/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
HIF1A Q16665 1/20 0.41
TAAR1 Q96RJ0 1/20 0.41
MMP2 P08253 1/20 0.40
TSHR P16473 1/20 0.39
LMNA P02545 1/20 0.39
CYP2D6 P10635 1/20 0.39
MAPT P10636 1/20 0.39
KMT2A Q03164 1/20 0.39
CTSC P53634 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Remacemide SCHEMBL20769836 0.98 CYP1A2 (1.00) MAPK1CYP1A2CYP3A4RECQLCYP2C19
Remacemide SCHEMBL151148 0.98 CYP1A2 (1.00) MAPK1CYP1A2CYP3A4RECQLCYP2C19
Remacemide SCHEMBL7266094 0.92 CYP3A4 (0.86) MAPK1CYP1A2CYP3A4RECQLCYP2C19
Remacemide SCHEMBL31270066 0.92 CYP3A4 (0.86) MAPK1CYP1A2CYP3A4RECQLCYP2C19
Remacemide SCHEMBL7266326 0.92 CYP3A4 (0.86) MAPK1CYP1A2CYP3A4RECQLCYP2C19
Hydrochloric Acid SCHEMBL9513957 0.90 MAPK1 (0.82) MAPK1CYP1A2CYP3A4RECQLCYP2C19
SCHEMBL5300822 0.90 CYP3A4 (0.84) MAPK1CYP1A2CYP3A4RECQLCYP2C19
SCHEMBL9054250 0.90 CYP3A4 (0.84) MAPK1CYP1A2CYP3A4RECQLCYP2C19
SCHEMBL5300046 0.90 CYP3A4 (0.84) MAPK1CYP1A2CYP3A4RECQLCYP2C19
Hydrochloric Acid SCHEMBL9172429 0.90 MAPK1 (0.81) MAPK1CYP1A2CYP3A4RECQLCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 335 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4623932-A1 AGENT FOR ALLEVIATING CLOZAPINE-INDUCED SIALORRHEA National University Corporation Chiba University (JP) 2025-10-01 EP claimed
WO-2024111636-A1 AGENT FOR ALLEVIATING CLOZAPINE-INDUCED SIALORRHEA 国立大学法人千葉大学 2024-05-30 WO claimed
US-20150119327-A1 DRUG SCREENING PLATFORM FOR RETT SYNDROME THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2015-04-30 US claimed
EP-2841067-A2 A DRUG SCREENING PLATFORM FOR RETT SYNDROME The Regents of The University of California (US) 2015-03-04 EP claimed
WO-2013163455-A2 A DRUG SCREENING PLATFORM FOR RETT SYNDROME THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-10-31 WO claimed
US-8268352-B2 Modified release composition for highly soluble drugs TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-18 US claimed
US-8263125-B2 Dosage form for high dose-high solubility active ingredients that provides for immediate release and modified release of the active ingredients TORRENT PHARMACEUTICALS LIMITED (IN) 2012-09-11 US claimed
WO-2011008298-A2 NOVEL AXOMADOL DOSAGE FORMS NECTID, INC. (US) 2011-01-20 WO claimed
WO-2008010794-A1 PHARMACEUTICAL PREPARATIONS OF CRYSTALLINE LAZABEMIDE RENAISSANCE MEDICINE, LLC (US) 2008-01-24 WO claimed
EP-1309301-A4 MEDICATED WRAP HYSON MORTON I (US) 2007-04-04 EP claimed
EP-1309301-A1 MEDICATED WRAP Hyson, Morton I. (US) 2003-05-14 EP claimed
EP-1175209-A2 USE OF ANTIEPILEPTICS FOR TREATING RESPIRATORY DISORDERS, IN PARTICULAR ASTHMATIC DISORDERS Lomia, Merab (GE) 2002-01-30 EP claimed
WO-2001080797-A1 MEDICATED WRAP HYSON MORTON I (US) 2001-11-01 WO claimed
EP-0946497-B1 PROCESS FOR THE PREPARATION OF NMDA ANTAGONISTS ASTRAZENECA AB (SE) 2001-10-17 EP claimed
WO-2000066096-A2 USE OF ANTIEPILEPTICS FOR TREATING RESPIRATORY DISORDERS, IN PARTICULAR ASTHMATIC DISORDERS LOMIA MERAB (GE) 2000-11-09 WO claimed
US-6063962-A Process for the preparation of NMDA antagonists ASTRA PHARMACEUTICALS LIMITED (GB) 2000-05-16 US claimed
EP-0946497-A1 PROCESS FOR THE PREPARATION OF NMDA ANTAGONISTS Astra Pharmaceuticals Limited (GB) 1999-10-06 EP claimed
WO-1998027052-A1 PROCESS FOR THE PREPARATION OF NMDA ANTAGONISTS ASTRA PHARMACEUTICALS LTD. (GB) 1998-06-25 WO claimed
EP-0279937-B1 2-AMINOACETAMIDE DERIVATIVES FISONS CORPORATION (US) 1991-10-09 EP claimed
EP-0279937-A1 2-Aminoacetamide derivatives FISONS CORPORATION (US) 1988-08-31 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150119327-A1 DRUG SCREENING PLATFORM FOR RETT SYNDROME GRIN2A, GRIN1, GRIN2B SLC6A2 272/4885MMP8 4705/4885MAPK1 1034/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.