⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2077079 | 1.00 | — | — | |
| SCHEMBL2077075 | 1.00 | — | — | |
| SCHEMBL2079681 | 0.84 | PIK3CD (0.31) | — | |
| SCHEMBL4762735 | 0.84 | PIK3CD (0.31) | — | |
| SCHEMBL2076943 | 0.81 | CCR2 (0.36) | — | |
| SCHEMBL2076947 | 0.81 | CCR2 (0.36) | — | |
| SCHEMBL2080884 | 0.76 | VDR (0.30) | — | |
| SCHEMBL2080887 | 0.76 | VDR (0.30) | — | |
| SCHEMBL2080889 | 0.76 | VDR (0.30) | — | |
| SCHEMBL17686396 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906532-B2 | Antiserotonine agents; gastrointestinal disorders; irritable bowel syndrome; central nervous system disorders; Alzheimer's disease; cognition activators; analgesics; cardiovascular disorders; antidiabetic agents; sleep disorders | PFIZER INC. (US) | 2011-03-15 | — | — | US | disclosed |
| EP-1910340-B1 | INDAZOLECARBOXAMIDE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS | PFIZER (US) | 2009-11-18 | — | — | EP | disclosed |
| US-20080269211-A1 | Indazole Derivatives | PFIZER INC | 2008-10-30 | — | — | US | disclosed |