Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.63 |
| ▸ | RXRB | P28702 | 6/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.52 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.52 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.48 |
| ▸ | RXRG | P48443 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20775328 | 0.86 | RAB9A (0.54) | RXRARXRBMEN1KMT2ARAB9A | |
| SCHEMBL22489859 | 0.83 | MAOB (0.63) | MEN1KMT2ARAB9ASMN1; SMN2SMPD1 | |
| SCHEMBL852236 | 0.83 | MEN1 (0.69) | RXRARXRBMEN1KMT2ANR4A2 | |
| SCHEMBL22247186 | 0.81 | SMPD1 (0.50) | RXRARXRBMEN1KMT2ARAB9A | |
| SCHEMBL14536502 | 0.81 | MEN1 (0.73) | RXRARXRBMEN1KMT2ANR4A2 | |
| SCHEMBL29010786 | 0.80 | MEN1 (0.64) | RXRARXRBMEN1KMT2ANR4A2 | |
| SCHEMBL3170471 | 0.80 | RXRA (0.73) | RXRARXRBMEN1KMT2ANR4A2 | |
| SCHEMBL200551 | 0.80 | MAOB (0.52) | RAB9ASMN1; SMN2NPC1POLBSMPD1 | |
| SCHEMBL28410872 | 0.80 | NR4A2 (0.64) | RXRARXRBMEN1KMT2ANR4A2 | |
| SCHEMBL24488963 | 0.78 | RXRA (1.00) | RXRARXRBNR4A2NR4A1NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11020381-B2 | Biaryloxy derivatives as TTX-S blockers | RAQUALIA PHARMA INC. (JP) | 2021-06-01 | — | — | US | disclosed |
| US-20200230123-A1 | BIARYLOXY DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2020-07-23 | — | — | US | disclosed |
| EP-3676248-A1 | BIARYLOXY DERIVATIVES AS TTX-S BLOCKERS | RaQualia Pharma Inc. (JP) | 2020-07-08 | — | — | EP | disclosed |
| CN-111132961-A | Bisaryloxy derivatives as TTX-S blockers | 拉夸里亚创药株式会社 | 2020-05-08 | — | — | CN | disclosed |
| WO-2019045035-A1 | BIARYLOXY DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2019-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11020381-B2 | Biaryloxy derivatives as TTX-S blockers | SCN1B, SCN3A, SCN2B | RXRA 3448/4885RXRB 2683/4885MEN1 3938/4885 |
| US-20200230123-A1 | BIARYLOXY DERIVATIVES AS TTX-S BLOCKERS | SCN1B, SCN3A, SCN2B | RXRA 3448/4885RXRB 2683/4885MEN1 3938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.