Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 18/20 | 0.80 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.78 |
| ▸ | BCL6 | P41182 | 1/20 | 0.64 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30611433 | 0.89 | ROCK2 (0.89) | ROCK2ROCK1 | |
| SCHEMBL20774589 | 0.89 | ROCK2 (0.89) | ROCK2ROCK1 | |
| SCHEMBL22126138 | 0.89 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20774617 | 0.89 | ROCK2 (0.77) | ROCK2ROCK1 | |
| SCHEMBL30611460 | 0.89 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL30611444 | 0.88 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL30611379 | 0.88 | ROCK2 (0.80) | ROCK2ROCK1BCL6NCOR2 | |
| SCHEMBL20783987 | 0.88 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20774825 | 0.88 | ROCK2 (0.80) | ROCK2ROCK1BCL6NCOR2 | |
| SCHEMBL20774595 | 0.88 | ROCK2 (1.00) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111587112-B | Rho-related inhibitors of coiled-coil-containing protein kinases | 卡德门企业有限公司 | 2023-10-10 | — | — | CN | disclosed |
| US-20230174519-A1 | Inhibitors of Rho Associated Coiled-Coil Containing Protein Kinase | KADMON CORPORATION, LLC (US) | 2023-06-08 | — | — | US | disclosed |
| US-20230174519-A1 | Inhibitors of Rho Associated Coiled-Coil Containing Protein Kinase | KADMON CORPORATION, LLC (US) | 2023-06-08 | — | — | US | disclosed |
| US-11613531-B2 | Inhibitors of RHO associated coiled-coil containing protein kinase | KADMON CORPORATION, LLC (US) | 2023-03-28 | — | — | US | disclosed |
| CN-111587112-A | Rho-related inhibitors of coiled coil protein kinase | 卡德门企业有限公司 | 2020-08-25 | — | — | CN | disclosed |
| EP-3675861-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | Kadmon Corporation, LLC (US) | 2020-07-08 | — | — | EP | disclosed |
| US-20200199109-A1 | Inhibitors of RHO Associated Coiled-Coil Containing Protein Kinase | KADMON CORPORATION, LLC | 2020-06-25 | — | — | US | disclosed |
| US-20200199109-A1 | Inhibitors of RHO Associated Coiled-Coil Containing Protein Kinase | KADMON CORPORATION, LLC | 2020-06-25 | — | — | US | disclosed |
| WO-2019045824-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | KADMON CORPORATION, LLC (US) | 2019-03-07 | — | — | WO | disclosed |
| WO-2019045824-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | KADMON CORPORATION, LLC (US) | 2019-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174519-A1 | Inhibitors of Rho Associated Coiled-Coil Containing Protein Kinase | ROCK1, ROCK2, RHOT2 | ROCK2 2/4885ROCK1 1/4885BCL6 1290/4885 |
| US-20200199109-A1 | Inhibitors of RHO Associated Coiled-Coil Containing Protein Kinase | ROCK1, ROCK2, RHOT2 | ROCK2 2/4885ROCK1 1/4885BCL6 1290/4885 |
| US-11613531-B2 | Inhibitors of RHO associated coiled-coil containing protein kinase | ROCK1, ROCK2, RHOT2 | ROCK2 2/4885ROCK1 1/4885BCL6 1290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.