Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.49 |
| ▸ | CCR2 | P41597 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20792300 | 1.00 | HSD11B1 (0.49) | HSD11B1CCR2JAK2JAK1TYK2 | |
| SCHEMBL20772683 | 0.86 | HSD11B1 (0.50) | HSD11B1CCR2OPRL1OPRM1OPRK1 | |
| SCHEMBL20111931 | 0.86 | HSD11B1 (0.54) | HSD11B1CCR2JAK2JAK1TYK2 | |
| SCHEMBL20772738 | 0.85 | HSD11B1 (0.48) | HSD11B1CCR2OPRL1OPRM1OPRK1 | |
| SCHEMBL21714519 | 0.82 | HSD11B1 (0.55) | HSD11B1CCR2JAK2JAK1TYK2 | |
| SCHEMBL20772746 | 0.82 | JAK1 (0.45) | HSD11B1JAK2JAK1TYK2JAK3 | |
| SCHEMBL2267177 | 0.82 | HSD11B1 (0.63) | HSD11B1JAK2JAK1TYK2JAK3 | |
| SCHEMBL23153231 | 0.81 | HSD11B1 (0.51) | HSD11B1CCR2JAK2JAK1TYK2 | |
| SCHEMBL21714364 | 0.81 | HSD11B1 (0.51) | HSD11B1CCR2JAK2JAK1TYK2 | |
| SCHEMBL21714117 | 0.81 | HSD11B1 (0.54) | HSD11B1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019043373-A1 | SUBSTITUTED CYCLYL-SULFONAMIDES AS MODULATORS OF HEDGEHOG (HH) SIGNALLING PATHWAY | E-THERAPEUTICS PLC (GB) | 2019-03-07 | — | — | WO | disclosed |