Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30402431 | 0.83 | ALDH1A1 (0.60) | KDM4EALDH1A1NPC1CA12CA1 | |
| SCHEMBL1962706 | 0.83 | ALDH1A1 (0.60) | KDM4EALDH1A1NPC1CA12CA1 | |
| SCHEMBL1911879 | 0.81 | NPC1 (0.69) | KDM4EALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL20522213 | 0.80 | KDM4E (0.60) | KDM4EALDH1A1NPC1CA12CA1 | |
| SCHEMBL10169462 | 0.80 | ALDH1A1 (0.60) | KDM4EALDH1A1NPC1CA12CA1 | |
| SCHEMBL538618 | 0.80 | ALDH1A1 (0.60) | KDM4EALDH1A1MAPK14NPC1CA12 | |
| SCHEMBL2816112 | 0.78 | ALDH1A1 (0.58) | KDM4EALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL12840673 | 0.78 | ALDH1A1 (0.54) | KDM4EALDH1A1MAPK14NPC1RAB9A | |
| SCHEMBL14224668 | 0.77 | ALDH1A1 (0.56) | KDM4EALDH1A1MAPK14NPC1CA12 | |
| SCHEMBL23906424 | 0.77 | MEN1 (0.56) | KDM4EALDH1A1MAPK14NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007773-B1 | THIAZOLYL DIHYDRO-INDAZOLES | BOEHRINGER INGELHEIM INT (DE) | 2012-10-24 | — | — | EP | disclosed |
| EP-2007773-B1 | THIAZOLYL DIHYDRO-INDAZOLES | BOEHRINGER INGELHEIM INT (DE) | 2012-10-24 | — | — | EP | disclosed |
| US-7902183-B2 | Thiazolyl-dihydro-indazole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-03-08 | — | — | US | disclosed |
| US-7902183-B2 | Thiazolyl-dihydro-indazole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-03-08 | — | — | US | disclosed |
| US-7902183-B2 | Thiazolyl-dihydro-indazole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-03-08 | — | — | US | disclosed |
| EP-2007773-A1 | THIAZOLYL DIHYDRO-INDAZOLES | Boehringer Ingelheim International GmbH (DE) | 2008-12-31 | — | — | EP | disclosed |
| US-20070270401-A1 | Thiazolyl-Dihydro-Indazole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-22 | — | — | US | disclosed |
| US-20070270401-A1 | Thiazolyl-Dihydro-Indazole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-22 | — | — | US | disclosed |
| US-20070270401-A1 | Thiazolyl-Dihydro-Indazole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-22 | — | — | US | disclosed |
| WO-2007113245-A1 | THIAZOLYL DIHYDRO-INDAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-11 | — | — | WO | disclosed |
| WO-2007113245-A1 | THIAZOLYL DIHYDRO-INDAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270401-A1 | Thiazolyl-Dihydro-Indazole | MKI67, INSR, CCNT1 | KDM4E 3502/4885ALDH1A1 44/4885MAPK14 2734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.