SCHEMBL20780187 — predicted protein targets

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	ALOX5	P09917	8/20	0.82

▸	GRM2	Q14416	6/20	0.35

▸	KCNH2	Q12809	1/20	0.35

▸	HPGD	P15428	3/20	0.34

▸	ALDH1A1	P00352	2/20	0.34

▸	KDM4E	B2RXH2	1/20	0.34

▸	LMNA	P02545	1/20	0.34

▸	USP2	O75604	1/20	0.33

▸	CA12	O43570	1/20	0.33

▸	CA9	Q16790	1/20	0.33

▸	NOD1	Q9Y239	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Setileuton SCHEMBL1528740	0.90	ALOX5 (1.00)	ALOX5GRM2KCNH2HPGDALDH1A1
Setileuton SCHEMBL1528741	0.90	ALOX5 (1.00)	ALOX5GRM2KCNH2HPGDALDH1A1
Setileuton SCHEMBL13691961	0.90	ALOX5 (1.00)	ALOX5GRM2KCNH2HPGDALDH1A1
Setileuton SCHEMBL29371714	0.90	ALOX5 (1.00)	ALOX5GRM2KCNH2HPGDALDH1A1
SCHEMBL4080470	0.86	ALOX5 (0.82)	ALOX5GRM2KCNH2HPGDALDH1A1
SCHEMBL4078770	0.85	ALOX5 (0.81)	ALOX5GRM2KCNH2HPGDALDH1A1
SCHEMBL15275058	0.85	ALOX5 (0.81)	ALOX5GRM2KCNH2HPGDALDH1A1
SCHEMBL13799549	0.85	ALOX5 (0.81)	ALOX5GRM2KCNH2HPGDALDH1A1
SCHEMBL4076137	0.85	ALOX5 (0.81)	ALOX5GRM2KCNH2HPGDALDH1A1
SCHEMBL4087806	0.83	ALOX5 (0.81)	ALOX5GRM2KCNH2HPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2019040346-A1	METHODS FOR PREPARING STABILIZED AMORPHOUS DRUG FORMULATIONS USING ACOUSTIC FUSION	MERCK SHARP & DOHME CORP. (US)	2019-02-28	—	—	WO	disclosed