SCHEMBL20780357

SCHEMBL20780357

N#Cc1ccccc1-n1c2ccccc2c2c(-c3cccc4c3c3ccccc3n4-c3ccccc3C#N)cccc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IMPDH2 P12268 1/20 0.39
MAT2A P31153 1/20 0.38
SMN1; SMN2 Q16637 4/20 0.37
ALDH1A1 P00352 4/20 0.37
RPS6KB1 P23443 1/20 0.37
ROCK1 Q13464 1/20 0.37
MAPT P10636 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
HIF1A Q16665 1/20 0.36
KDM4E B2RXH2 2/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
TDP1 Q9NUW8 2/20 0.35
TSHR P16473 1/20 0.35
STAT3 P40763 1/20 0.33
ESR2 Q92731 1/20 0.33
AR P10275 1/20 0.33
POLB P06746 1/20 0.33
KCNN4 O15554 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18347452 0.94 IMPDH2 (0.36) IMPDH2MAT2ASMN1; SMN2ALDH1A1RPS6KB1
SCHEMBL22152921 0.90 IMPDH2 (0.41) IMPDH2MAT2ASMN1; SMN2ALDH1A1RPS6KB1
SCHEMBL20413223 0.89 IMPDH2 (0.42) IMPDH2MAT2ASMN1; SMN2ALDH1A1RPS6KB1
SCHEMBL21202461 0.87 KDM4E (0.40) IMPDH2MAT2ASMN1; SMN2ALDH1A1RPS6KB1
SCHEMBL20780358 0.87 RPS6KB1 (0.36) IMPDH2MAT2AALDH1A1RPS6KB1MAPT
SCHEMBL20780505 0.87 CYP1A2 (0.36) IMPDH2MAT2ASMN1; SMN2ALDH1A1RPS6KB1
SCHEMBL18348473 0.86 KDM4E (0.39) IMPDH2MAT2ASMN1; SMN2ALDH1A1RPS6KB1
SCHEMBL18348405 0.86 KDM4E (0.39) IMPDH2MAT2ASMN1; SMN2ALDH1A1RPS6KB1
SCHEMBL18347463 0.85 RORC (0.33) IMPDH2MAT2AALDH1A1RPS6KB1ROCK1
SCHEMBL27301199 0.85 SMN1; SMN2 (0.38) MAT2ASMN1; SMN2ALDH1A1RPS6KB1ROCK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190074467-A1 SOLVENT COATABLE OLED EMITTER COMPOSITION CONTAINING NON-PLASMONIC MOLECULAR NOBLE METAL NANOPARTICLES AND EMITTER MATERIALS IN NONCRYSTALLIZABLE MOLECULAR ORGANIC SEMICONDUCTORS MOLECULAR GLASSES, INC. (US) 2019-03-07 US disclosed