Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | KCNQ3 | O43525 | 4/20 | 0.49 |
| ▸ | KCNQ2 | O43526 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20767333 | 0.86 | RAB9A (0.51) | RAB9ASMN1; SMN2NPC1KMT2AMEN1 | |
| SCHEMBL20767328 | 0.82 | RAB9A (0.53) | RAB9ASMN1; SMN2NPC1KCNQ3KCNQ2 | |
| SCHEMBL23846630 | 0.82 | NPC1 (0.47) | RAB9ASMN1; SMN2NPC1KCNQ3KCNQ2 | |
| SCHEMBL25754391 | 0.80 | IDH1 (0.52) | RAB9ASMN1; SMN2NPC1KMT2AMEN1 | |
| SCHEMBL16926480 | 0.78 | NPC1 (0.55) | RAB9ANPC1ALDH1A1LMNAGAA | |
| SCHEMBL17465717 | 0.73 | RAB9A (0.55) | RAB9ASMN1; SMN2NPC1KMT2AMEN1 | |
| SCHEMBL18068209 | 0.71 | SMN1; SMN2 (0.52) | RAB9ASMN1; SMN2NPC1HTTSORT1 | |
| SCHEMBL17001138 | 0.70 | NPC1 (0.37) | RAB9ANPC1KMT2AMEN1TP53 | |
| SCHEMBL31200262 | 0.70 | MAOA (0.42) | RAB9ASMN1; SMN2NPC1KMT2AMEN1 | |
| SCHEMBL20459098 | 0.70 | RAB9A (0.51) | RAB9ASMN1; SMN2NPC1KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019040102-A1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2019-02-28 | — | — | WO | disclosed |