Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.96 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20774728 | 0.98 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20784036 | 0.86 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20774886 | 0.85 | ROCK2 (0.78) | ROCK2ROCK1 | |
| SCHEMBL20774709 | 0.82 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL25630335 | 0.81 | ROCK2 (0.68) | ROCK2ROCK1 | |
| SCHEMBL20774771 | 0.80 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20774792 | 0.79 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20784059 | 0.77 | ROCK2 (0.75) | ROCK2ROCK1 | |
| SCHEMBL20774897 | 0.76 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL25630333 | 0.74 | ROCK2 (0.78) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019045824-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | KADMON CORPORATION, LLC (US) | 2019-03-07 | — | — | WO | disclosed |