Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 15/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.68 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20784059 | 0.88 | ROCK2 (0.75) | ROCK2ROCK1HSP90AA1HSP90AB1 | |
| SCHEMBL25630333 | 0.85 | ROCK2 (0.78) | ROCK2ROCK1ACHE | |
| SCHEMBL25630336 | 0.83 | MAPK8 (0.52) | ROCK2ROCK1MAPK8CDC7HSP90AA1 | |
| SCHEMBL15698538 | 0.83 | CCNE1 (0.61) | ROCK2ROCK1MAPK8CDC7HSP90AA1 | |
| SCHEMBL20784036 | 0.81 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20783908 | 0.81 | ROCK2 (0.96) | ROCK2ROCK1 | |
| SCHEMBL20774897 | 0.80 | ROCK2 (1.00) | ROCK2ROCK1HSP90AA1HSP90AB1 | |
| SCHEMBL28296626 | 0.79 | ACHE (0.50) | ROCK2ROCK1MAPK8CDC7HSP90AA1 | |
| SCHEMBL20774728 | 0.78 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL20774709 | 0.78 | ROCK2 (1.00) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174519-A1 | Inhibitors of Rho Associated Coiled-Coil Containing Protein Kinase | KADMON CORPORATION, LLC (US) | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174519-A1 | Inhibitors of Rho Associated Coiled-Coil Containing Protein Kinase | ROCK1, ROCK2, RHOT2 | ROCK2 2/4885ROCK1 1/4885MAPK8 687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.