Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 7/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19329144 | 0.81 | ALDH1A1 (0.46) | ALDH1A1MEN1S1PR1KMT2AKDM4E | |
| SCHEMBL23996994 | 0.81 | TLR8 (0.50) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL19356293 | 0.81 | S1PR1 (0.52) | ALDH1A1MEN1S1PR1KMT2AKDM4E | |
| SCHEMBL23571715 | 0.73 | ALDH1A1 (0.59) | ALDH1A1KDM4EMAPK1RAB9ATLR8 | |
| SCHEMBL29133063 | 0.72 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL21939282 | 0.68 | TLR8 (0.55) | TLR8TLR7TLR9LRRK2MAPT | |
| SCHEMBL19428321 | 0.68 | CA1 (0.60) | ALDH1A1KMT2AKDM4EHPGDHSD17B10 | |
| SCHEMBL19078690 | 0.68 | KDM4E (0.50) | ALDH1A1MEN1KMT2AKDM4EHPGD | |
| SCHEMBL19427972 | 0.67 | POLB (0.62) | ALDH1A1KMT2AKDM4EHPGDHSD17B10 | |
| SCHEMBL21958358 | 0.67 | TLR8 (0.56) | ALDH1A1MEN1KMT2AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10421743-B2 | Tetrahydroisoquinolines as PRMT5 inhibitors | CTXT PTY LTD (AU) | 2019-09-24 | — | — | US | disclosed |
| US-20190071425-A1 | TETRAHYDROISOQUINOLINES AS PRMT5 INHIBITORS | CTXT PTY LTD (AU) | 2019-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190071425-A1 | TETRAHYDROISOQUINOLINES AS PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT3 | ALDH1A1 4294/4885MEN1 162/4885S1PR1 2730/4885 |
| US-10421743-B2 | Tetrahydroisoquinolines as PRMT5 inhibitors | PRMT5, PRMT1, PRMT3 | ALDH1A1 4294/4885MEN1 162/4885S1PR1 2730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.