Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 17/20 | 0.56 |
| ▸ | HTR2A | P28223 | 15/20 | 0.56 |
| ▸ | HTR2B | P41595 | 14/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2078547 | 1.00 | HTR2C (0.56) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL17760134 | 0.83 | HTR2C (0.42) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL30640672 | 0.77 | CYP19A1 (0.43) | HTR2CHTR2AHTR2B | |
| SCHEMBL10054051 | 0.77 | CYP19A1 (0.43) | HTR2CHTR2AHTR2B | |
| SCHEMBL15761050 | 0.77 | CYP19A1 (0.43) | HTR2CHTR2AHTR2B | |
| SCHEMBL25518406 | 0.77 | CYP19A1 (0.43) | HTR2CHTR2AHTR2B | |
| SCHEMBL31569035 | 0.76 | MAOA (0.39) | HTR2CHTR2AHTR2B | |
| SCHEMBL31569493 | 0.76 | MAOA (0.39) | HTR2CHTR2AHTR2B | |
| SCHEMBL790256 | 0.76 | MAOA (0.39) | HTR2CHTR2AHTR2B | |
| SCHEMBL31568999 | 0.76 | MAOA (0.39) | HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897595-B2 | Pyridoazepine derivatives | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2011-03-01 | — | — | US | disclosed |
| US-20070281918-A1 | PYRIDOAZEPINE DERIVATIVES | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281918-A1 | PYRIDOAZEPINE DERIVATIVES | HTR2C, HTR5A, HTR2A | HTR2C 1/4885HTR2A 3/4885HTR2B 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.