Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.46 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 3/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1500323 | 0.86 | HDAC3 (0.43) | PRMT5WDR77SRD5A1PARP1PARP10 | |
| SCHEMBL29644814 | 0.83 | PRMT5 (0.45) | PRMT5WDR77SRD5A1SRD5A2PARP1 | |
| SCHEMBL5796029 | 0.81 | PRMT5 (0.47) | PRMT5WDR77SRD5A1GRM5PARP10 | |
| SCHEMBL27822202 | 0.81 | PRMT5 (0.47) | PRMT5WDR77SRD5A1GRM5ITGB3 | |
| SCHEMBL16620172 | 0.80 | AR (0.52) | SRD5A1AR | |
| SCHEMBL1817669 | 0.79 | GRM5 (0.61) | PRMT5WDR77SRD5A1GRM5HRH3 | |
| SCHEMBL25362979 | 0.79 | AOC3 (0.48) | PRMT5WDR77ITGB3ITGA2B | |
| SCHEMBL30530638 | 0.79 | AOC3 (0.48) | PRMT5WDR77ITGB3ITGA2B | |
| SCHEMBL24934195 | 0.78 | PRMT5 (0.53) | PRMT5WDR77SRD5A1GRM5PARP10 | |
| SCHEMBL20985808 | 0.78 | ITGB3 (0.59) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3453707-B1 | BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI DE NOVO PHARMATECH CO LTD (CN) | 2022-02-16 | — | — | EP | disclosed |
| CN-107344931-B | Benzazepine derivative, preparation method thereof, pharmaceutical composition and application thereof | 上海迪诺医药科技有限公司 | 2020-09-15 | — | — | CN | disclosed |
| EP-3453707-A1 | BENZAZEPINE DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Shanghai de Novo Pharmatech Co., Ltd. (CN) | 2019-03-13 | — | — | EP | disclosed |