Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 0.54 |
| ▸ | JAK2 | O60674 | 10/20 | 0.54 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20119098 | 0.91 | NTRK1 (0.58) | NTRK1JAK2 | |
| SCHEMBL21319475 | 0.91 | NTRK1 (0.50) | NTRK1JAK2 | |
| SCHEMBL20119126 | 0.91 | NTRK1 (0.58) | NTRK1JAK2 | |
| SCHEMBL22151237 | 0.89 | NTRK1 (0.56) | NTRK1JAK2 | |
| SCHEMBL20795495 | 0.88 | NTRK1 (0.60) | NTRK1JAK2 | |
| SCHEMBL30480053 | 0.88 | NTRK1 (0.60) | NTRK1JAK2 | |
| SCHEMBL20795390 | 0.88 | NTRK1 (0.60) | NTRK1JAK2 | |
| SCHEMBL21319473 | 0.83 | NTRK1 (0.57) | NTRK1JAK2 | |
| SCHEMBL21319504 | 0.83 | NTRK1 (0.57) | NTRK1JAK2 | |
| SCHEMBL24168761 | 0.82 | NTRK1 (0.65) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3674307-B1 | MACROCYCLE CONTAINING AMINOPYRAZOLE AND PYRIMIDINE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2023-06-07 | — | — | EP | disclosed |
| US-20200291042-A1 | MACROCYCLE CONTAINING AMINOPYRAZOLE AND PYRIMIDINE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. (CN) | 2020-09-17 | — | — | US | disclosed |
| EP-3674307-A1 | MACROCYCLE CONTAINING AMINOPYRAZOLE AND PYRIMIDINE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2020-07-01 | — | — | EP | disclosed |
| WO-2019037761-A1 | MACROCYCLE CONTAINING AMINOPYRAZOLE AND PYRIMIDINE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 正大天晴药业集团股份有限公司 | 2019-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200291042-A1 | MACROCYCLE CONTAINING AMINOPYRAZOLE AND PYRIMIDINE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | MUSK, TK1, TYMP | NTRK1 105/4885JAK2 1048/4885NTRK3 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.