Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9268169 | 0.82 | MBD2 (0.66) | MBD2ADORA2AALDH1A1LMNAKDM4E | |
| SCHEMBL13394327 | 0.81 | MBD2 (0.64) | MBD2ADORA2AALDH1A1LMNAKDM4E | |
| SCHEMBL13408418 | 0.78 | MBD2 (0.76) | MBD2ADORA2AALDH1A1LMNAKDM4E | |
| SCHEMBL13390176 | 0.75 | MBD2 (1.00) | MBD2ADORA2AALDH1A1LMNAGAA | |
| SCHEMBL8202303 | 0.72 | MBD2 (0.54) | MBD2ALDH1A1LMNAHPGD | |
| SCHEMBL9258018 | 0.70 | MBD2 (0.51) | MBD2ADORA2AALDH1A1LMNAKDM4E | |
| SCHEMBL9257171 | 0.69 | MBD2 (0.50) | MBD2ADORA2AALDH1A1LMNAKDM4E | |
| SCHEMBL21412940 | 0.69 | MBD2 (0.50) | MBD2ADORA2AALDH1A1LMNAKDM4E | |
| SCHEMBL9262702 | 0.69 | MBD2 (0.50) | MBD2ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL8878415 | 0.68 | MBD2 (0.48) | MBD2ADORA2AALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227654-B2 | Agents for reversing epigenetic silencing of genes | THE JOHNS HOPKINS UNIVERSITY (US) | 2019-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227654-B2 | Agents for reversing epigenetic silencing of genes | MECP2, MBD2, GATAD2B | MBD2 2/4885ADORA2A 3196/4885ALDH1A1 2323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.