Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17967362 | 0.81 | SMN1; SMN2 (0.44) | PTGS2ESR1CYP19A1CYP11B2ALOX15 | |
| SCHEMBL17967369 | 0.81 | MAPT (0.47) | PTGS2ESR1CYP19A1CYP11B2MAPT | |
| SCHEMBL17967358 | 0.81 | SMN1; SMN2 (0.44) | PTGS2ESR1CYP19A1CYP11B2ALOX15 | |
| SCHEMBL17967368 | 0.81 | MAPT (0.47) | PTGS2ESR1CYP19A1CYP11B2MAPT | |
| SCHEMBL17967365 | 0.81 | NFE2L2 (0.42) | NFE2L2ALOX15MAPTALDH1A1HSD17B10 | |
| SCHEMBL17967366 | 0.81 | NFE2L2 (0.42) | NFE2L2ALOX15MAPTALDH1A1HSD17B10 | |
| SCHEMBL17967346 | 0.81 | MAPT (0.49) | ESR1CYP19A1MAPTALDH1A1NPC1 | |
| SCHEMBL17967344 | 0.81 | MAPT (0.49) | ESR1CYP19A1MAPTALDH1A1NPC1 | |
| SCHEMBL8641797 | 0.80 | MAPT (0.50) | PTGS2ESR1CYP19A1CYP11B2MAPT | |
| SCHEMBL7646238 | 0.80 | MAPT (0.50) | PTGS2ESR1CYP19A1CYP11B2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227355-B2 | Quinoline derivatives and preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2019-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227355-B2 | Quinoline derivatives and preparation thereof | ABL1, FLT3, MAP3K7 | PTGS2 2381/4885ESR1 3106/4885CYP19A1 495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.