Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | ACACA | Q13085 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20474256 | 0.85 | KDM4E (0.53) | KDM4EMEN1KMT2ASMN1; SMN2GABRA1 | |
| SCHEMBL20474189 | 0.81 | ALDH1A1 (0.50) | KDM4EMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL20474245 | 0.79 | PRNP (0.45) | MEN1KMT2ASMN1; SMN2GABRA1GABRG2 | |
| SCHEMBL30440258 | 0.79 | PIK3CA (0.57) | KDM4EMEN1KMT2ASMN1; SMN2EGFR | |
| SCHEMBL13865282 | 0.78 | POLB (0.47) | KDM4EGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL28176611 | 0.78 | PSMB5 (0.51) | KDM4EMEN1KMT2ACSF1RALDH1A1 | |
| SCHEMBL11166756 | 0.77 | TLR7 (0.51) | KDM4ESMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL17967312 | 0.77 | ALDH1A1 (0.49) | KDM4EKMT2ASMN1; SMN2GABRA1GABRG2 | |
| SCHEMBL28494948 | 0.76 | AURKA (0.57) | KDM4EMEN1KMT2ASMN1; SMN2ACACA | |
| SCHEMBL28350370 | 0.74 | KDM4E (0.75) | KDM4EMEN1KMT2ASMN1; SMN2ACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227355-B2 | Quinoline derivatives and preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2019-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227355-B2 | Quinoline derivatives and preparation thereof | ABL1, FLT3, MAP3K7 | KDM4E 939/4885MEN1 1505/4885KMT2A 870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.