Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9232313 | 0.77 | TYK2 (0.40) | MAPTTDP1L3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL3108323 | 0.75 | MMP2 (0.42) | MAPTTDP1L3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL12747503 | 0.72 | TYK2 (0.40) | MAPTTDP1L3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL14467741 | 0.72 | IDH1 (0.44) | MAPTSMN1; SMN2MAPK1KDM4EPOLB | |
| SCHEMBL20687681 | 0.71 | GRM1 (0.49) | MAPTMEN1KMT2AGRM1LMNA | |
| SCHEMBL24880689 | 0.70 | TYK2 (0.45) | — | |
| SCHEMBL21227516 | 0.70 | TYK2 (0.45) | — | |
| SCHEMBL21285237 | 0.70 | PTGS1 (0.44) | MAPTSMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL20687683 | 0.68 | TYK2 (0.44) | MAPTL3MBTL1POLBALDH1A1MEN1 | |
| SCHEMBL20688057 | 0.68 | TYK2 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019050924-A1 | COMBINATION THERAPY FOR TREATING CANCER | Epizyme, Inc. (US) | 2019-03-14 | — | — | WO | disclosed |