Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FURIN | P09958 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 7/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24611248 | 1.00 | FURIN (0.45) | FURINHTTLMNAMAPTL3MBTL1 | |
| SCHEMBL21157965 | 0.91 | FURIN (0.38) | FURINHTTSMN1; SMN2SIRT2SIRT1 | |
| SCHEMBL19302502 | 0.90 | FURIN (0.45) | FURINHTTLMNAMAPTL3MBTL1 | |
| SCHEMBL27291528 | 0.88 | FURIN (0.49) | FURINHTTLMNAMAPTL3MBTL1 | |
| SCHEMBL20803558 | 0.88 | SIRT2 (0.41) | FURINHTTSMN1; SMN2SIRT2SIRT1 | |
| SCHEMBL22064590 | 0.87 | FURIN (0.51) | FURINHTTLMNAL3MBTL1TP53 | |
| SCHEMBL20149172 | 0.87 | FURIN (0.49) | FURINHTTLMNAMAPTL3MBTL1 | |
| SCHEMBL24822727 | 0.86 | SIRT2 (0.44) | HTTSMN1; SMN2SIRT2SIRT1SIRT3 | |
| SCHEMBL17086814 | 0.86 | SIRT2 (0.44) | HTTSIRT2SIRT1SIRT3 | |
| SCHEMBL24086378 | 0.86 | SPHK1 (0.49) | HTTLMNAMAPTL3MBTL1CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019051489-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE | SPEROVIE BIOSCIENCES, INC. (US) | 2019-03-14 | — | — | WO | disclosed |